Everyday a new drug is introduced into the market with manufacturers guaranteeing positive results. This right here is all too uncommon particularly in medicine where laboratory experiments and studies are conducted almost everyday. A new and remarkable form of therapy was discovered for the treatment of diseases caused by an over reactive or abnormal immune system, treatment was given using liposomal clodronate.
The immune system is one of the most important system of the body specifically to one's health. In fact, some people take vitamin supplements to aid their immune system. The stronger it is, the more invincible man becomes. It's all very simple if you think of it, however this may not always be the case sometimes, there are abnormalities in your immune system which causes your cells to attach your own body, hence the term Autoimmune Disease.
Originally clodronic acid is biphosphonate, anti-osteoporotic drug. It was approved for the treatment and prevention of osteoporosis particularly to women and hyperparathyroidism, hypercalcemia and vertebral fracture to men. It was noticed that clodronic acid has a potent analgesic and anti inflammatory effects as it significantly reduced important inflammatory markers.
Clodronic acids is a first generation biphosphonate was originally used for the prevention and treatment of osteoporosis and reduce the risk of hyperparathyroidism, vertebral fractures, fracture related pain and hypercalcemia. It was during this time that the drug was discovered to have an effect in the immune system by reducing certain inflammatory markers.
Clodronic acid liposome therapy, targets the macrophages to efficiently halt the attack of healthy cells. Suppressing your macrophages will slow down inflammation thus decreasing the pace of disease progression. Some autoimmune diseases have life threatening effect when not intervened properly, for an instance in myasthenia gravis.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
Using the liposomes as a drug vehicle, clodronic acid will be delivered into your phagocytic cell, or macrophages damaging it irreversibly then kills it eventually through apoptosis. Aptly name as the macrophage "suicide'', this will result to a decreased or minimal immune reaction hence patients with autoimmune disease may show improvement from their condition.
With the discovery of these new therapy, it surely increases the hope of anyone suffering from severe autoimmune diseases to achieve disease remission. This may also decrease the chances of transplant rejection to those patients scheduled for transplantation in any parts of the body. All in all, clodronic acid liposome therapy is promising a good quality of life among patients.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
The immune system is one of the most important system of the body specifically to one's health. In fact, some people take vitamin supplements to aid their immune system. The stronger it is, the more invincible man becomes. It's all very simple if you think of it, however this may not always be the case sometimes, there are abnormalities in your immune system which causes your cells to attach your own body, hence the term Autoimmune Disease.
Originally clodronic acid is biphosphonate, anti-osteoporotic drug. It was approved for the treatment and prevention of osteoporosis particularly to women and hyperparathyroidism, hypercalcemia and vertebral fracture to men. It was noticed that clodronic acid has a potent analgesic and anti inflammatory effects as it significantly reduced important inflammatory markers.
Clodronic acids is a first generation biphosphonate was originally used for the prevention and treatment of osteoporosis and reduce the risk of hyperparathyroidism, vertebral fractures, fracture related pain and hypercalcemia. It was during this time that the drug was discovered to have an effect in the immune system by reducing certain inflammatory markers.
Clodronic acid liposome therapy, targets the macrophages to efficiently halt the attack of healthy cells. Suppressing your macrophages will slow down inflammation thus decreasing the pace of disease progression. Some autoimmune diseases have life threatening effect when not intervened properly, for an instance in myasthenia gravis.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
Using the liposomes as a drug vehicle, clodronic acid will be delivered into your phagocytic cell, or macrophages damaging it irreversibly then kills it eventually through apoptosis. Aptly name as the macrophage "suicide'', this will result to a decreased or minimal immune reaction hence patients with autoimmune disease may show improvement from their condition.
With the discovery of these new therapy, it surely increases the hope of anyone suffering from severe autoimmune diseases to achieve disease remission. This may also decrease the chances of transplant rejection to those patients scheduled for transplantation in any parts of the body. All in all, clodronic acid liposome therapy is promising a good quality of life among patients.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
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